Typical medical tests for biomarkers and drugs rely on liquid chromatography-mass spectrometry (LC-MS), an expensive, slow technique that often requires external lab analysis, making it not suitable for point-of-care use. We developed rapid (~ min), inexpenisve (< $2/test) apatsensors based on graphene field-effect transistors to detect anti-HIV drug, whic paves the way for new methods of measuring these markers with high efficency in cost and time.
DNA-based aptamers hold great promise to serve as the recgonizer of biosensors. We developed a methodlogy for scallable production of biosensors based on graphene-aptamer hybrids, paving the way for point-of-use theraputic drug detection.
The paper was published in mSphere.
Nanoparticle-driven current is measured with a graphene electrode to quantify the pore-size of the ferritin enclosing the nanoparticle. It was found that for open-pore ferritin, the size and shape of the pore is very likely to be retained when a gold nanoparticle is enclosed in the cage. This research first characterized the structure and function of protein-nanoparticle assemblies in solution and implies the potential of using graphene-based charge measurement technology to develop low-cost high-sensitivity disease diagnostic systems.
Intrinsic Faradaic charge follows into flexible graphene microelectrode in the absence of any bias. The characteristic current responds sensitively and rapidly to pH variation of complex biofluids. The results shed light on the polarity of the electrical double layer above graphene and pave the way for early cancer diagnosis via extracelluar pH monitoring.
The paper was published in Small.
I developed a methodology for scalable production of graphene-based DNA biosensor array with record-braking sensitivity 1 fM. That is, ~60,000 DNA molecules in a 1 mL drop of solution, or, one grain of salt (1g) dissolve into 6,800,000 international standard swimming pool.
The paper was published in ACS Nano.
We developed a scallable production method for four-probe transistor arrays with a novel configuration that comprises nano-bio hybrids of DNA, monodisperse gold nanoparticles (AuNPs), and graphene.
The paper was published in ACS Applied Materials and Interfaces.
MoTe2 monolayers with size ~102 were prepared with chemical vapor depostion. The synthesized 1T'-phase MoTe2 monolayers demonstrate clear weak anti-localization effects that are associated with spin-orbit coupling of topological insulators.
The paper can be found in Nano Letters.
Pico-Ampere-level of Fradaic current from ionic solution to graphene was measured at room temperature through a feedback capacitor. In the absence of bias, this spontaneous Faradaic current was driven at the graphene-solution interface. This technique paves the way for non-perturbative probing aquoues bio-systems.
The paper was picked by the Editors of Applied Physics Letters.
Nanohybrid of graphene and platinum nanoparticle was used as conducting channels in field-effect transistors. Functionalized with genetically engineered antibody, the transistors demonstrated high sensibility (300 fg mL-1) for detection of HER3, the breast cancer biomarker.
The paper was picked by the Editors of Advanced Materials Interfaces.
Liquid-based applications of biomolecule-decorated field-effect transistors (FETs) range from biosensors to in vivo implants. A critical scientific challenge is to develop a quantitative understanding of the gating effect of charged biomolecules in ionic solution and how this influences the readout of the FETs. To address this issue, we fabricated protein-decorated graphene FETs and measured their electrical properties, specifically the shift in Dirac voltage, in solutions of varying ionic strength. We found excellent quantitative agreement with a model that accounts for both the graphene polarization charge and ionic screening of ions adsorbed on the graphene as well as charged amino acids associated with the immobilized protein. The technique and analysis presented here directly couple the charging status of bound biomolecules to readout of liquid-phase FETs fabricated with graphene or other two-dimensional materials.
The paper can be found in Biosensors and Bioelectronics.
By using a seeded growth technique, semiconducting MoS2 monolayers with mobility ~10 cm2V-1s-1 were deposited at desired positions on SiO2 substrate—a needed enabling step for scalable production of devices based on discontinuous two-dimensional materials.
The paper can be found in Nature Communications.
Quadratic magnetoresistance is often constrained only to systems with more than one electron band. I demonstrated that for single-band two-dimensional electron systems, quadraltic magnetoresistance can be induced by disorder of the systems.
The paper was highlighted in Editor's Suggestion of Physics Review Letters and Highlights in Nanotechnology.
I discovered as-grown impurities with graphene synthesized on platinum via chemical vapor deposition, which are nanocrystalline graphene uncoverred by electron diffraction. I also proved that these impurites are grown UNDER a monolayer graphene.
I developed a methodlogy using the diffraction and dark-field technique of transmission electron microscopy (TEM) to measure the layer-number and stacking-order of graphene up to seven(7) layers.
The paper is one of the 20 most download papers of the month in Nano Letters.